You should not use Premarin if you are allergic to it or any of its inactive ingredients. You should not use Premarin if you have:
- unusual vaginal bleeding that has not been checked by a doctor;
- liver disease;
- a history of heart attack, stroke, or blood clot;
- an increased risk of having blood clots due to a heart problem or a hereditary blood
- disorder; or
- a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.
Do not use Premarin if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Estrogen should not be used to prevent heart disease, stroke, or dementia.