Crestor (Rosuvastatin)

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use exactly as directed by your healthcare provider.

Rosuvastatin is usually taken in adults 5 to 40 mg once a day, with or without food. Take the medicine at the same time each day.

For dosing in children:

In the heterozygous familial type:

• 5 to 10 mg orally once daily in patients 8 to less than 10 years of age,  
• 5 to 20 mg orally once daily in patients 10 to 17 years of age. 

In the homozygous familial type:

• 20 mg orally once daily in patients 7 to 17 years of age.

While using rosuvastatin, you may need frequent blood tests. 

Keep using this medicine as directed, even if you feel well. High cholesterol usually has no symptoms. You may need to take rosuvastatin on a long-term basis.

You should not stop using rosuvastatin unless your doctor tells you to.

Rosuvastatin is only part of a treatment program that may also include diet, exercise, and weight control. Follow your doctor’s instructions very closely.

If overdose is suspected, seek emergency medical attention.

If you miss a dose, take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not use two doses at one time. Do not take 2 doses on the same day.

Store at room temperature; away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

You should not take rosuvastatin if you are allergic to it, or if you have:

● liver disease; or

● if you are pregnant or breast-feeding.

Do not take rosuvastatin if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are taking rosuvastatin. Stop taking rosuvastatin and tell your doctor right away if you become pregnant.

Rosuvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking rosuvastatin.

Avoid eating foods high in fat or cholesterol, or rosuvastatin will not be as effective.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Some antacids can make it harder for your body to absorb rosuvastatin. Avoid taking an antacid that contains aluminum or magnesium within 2 hours after taking rosuvastatin.

Tell your doctor if you have ever had:

● liver problems;

● kidney disease;

● a thyroid disorder;

● a habit of drinking more than 2 alcoholic beverages per day;

● if you are of Asian descent; or

● if you are 65 or older.

Rosuvastatin can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

People of Asian descent may absorb rosuvastatin at a higher rate than other people. Make sure your doctor knows of your heritage if you are of Asian descent. You may need a lower than normal starting dose.

What are the possible side effects of Crestor (rosuvastatin)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

● unexplained muscle pain, tenderness, or weakness;

● confusion, memory problems; or

● liver problems–upper stomach pain, tired feeling, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes).

Common side effects may include:

● headache;

● weakness;

● memory loss;

● muscle aches and joint pain; or

● nausea, stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Tell your doctor about all your other medicines, especially:

● colchicine;

● cyclosporine; ● another “statin” medicine–atorvastatin, lovastatin, simvastatin, Lipitor, Pravachol, Zocor, Vytorin, and others;

● antifungal medicine–fluconazole, itraconazole, ketoconazole;

● antiviral medicine to treat HIV or hepatitis C–atazanavir, fosamprenavir, lopinavir, ritonavir, simeprevir, tipranavir, and others;

● a blood thinner–warfarin, Coumadin, Jantoven;

● other cholesterol medications–fenofibrate, gemfibrozil; or

● medicines that contain niacin or nicotinic acid–vitamin B3, Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others.

This list is not complete. Other drugs may affect this medication, including prescription and over-the-counter medicines, vitamins, and herbal products.

Seek emergency medical attention

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