Product Information
The use of Sabril or the generic equivalent, vigabatrin, comes with the risk of serious side effects including the following:
Permanent vision loss
Magnetic resonance imaging (MRI) changes in babies with infantile spasms (IS)
Risk of suicidal thoughts or actions
Please review the following Medication Guide prior to using Sabril or vigabatrin:
Sabril (vigabatrin) Medication Guide
WARNING: PERMANENT VISION LOSS
SABRIL can cause permanent bilateral concentric visual field constriction including tunnel vision that can result in disability. In some cases, SABRIL also can damage the central retina and may decrease visual acuity [see Warnings and Precautions (5.1)].
The onset of vision loss from SABRIL is unpredictable, and can occur within weeks of starting treatment or sooner, or at any time after starting treatment, even after months or years.
Symptoms of vision loss from SABRIL are unlikely to be recognized by patients or caregivers before vision loss is severe. Vision loss of milder severity, while often unrecognized by the patient or caregiver, can still adversely affect function.
The risk of vision loss increases with increasing dose and cumulative exposure, but there is no dose or exposure known to be free of risk of vision loss.
Vision assessment is recommended at baseline (no later than 4 weeks after starting SABRIL), at least every 3 months during therapy, and about 3 to 6 months after the discontinuation of therapy.
Once detected, vision loss due to SABRIL is not reversible. It is expected that, even with frequent monitoring, some patients will develop severe vision loss.
Consider drug discontinuation, balancing benefit and risk, if visual loss is documented.
Risk of new or worsening vision loss continues as long as SABRIL is used. It is possible that vision loss can worsen despite discontinuation of SABRIL.
Because of the risk of visual loss, SABRIL should be withdrawn from patients with refractory complex partial seizures who fail to show substantial clinical benefit within 3 months of initiation and within 2-4 weeks of initiation for patients with infantile spasms, or sooner if treatment failure becomes obvious. Patient response to and continued need for SABRIL should be periodically reassessed.
SABRIL should not be used in patients with, or at high risk of, other types of irreversible vision loss unless the benefits of treatment clearly outweigh the risks.
SABRIL should not be used with other drugs associated with serious adverse ophthalmic effects such as retinopathy or glaucoma unless the benefits clearly outweigh the risks.
Use the lowest dosage and shortest exposure to SABRIL consistent with clinical objectives [see Dosage and Administration (2.1)].
Because of the risk of permanent vision loss, SABRIL is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the Vigabatrin REMS Program [see Warnings and Precautions (5.2)]. Further information is available at www.vigabatrinREMS.com or 1-866-244-8175.
Other Information
Description of Sabril
Uses of Sabril
Available dosage forms and strengths
How should you take Sabril
Precautions and contraindications for Sabril
In case of overdosage
Warnings and Cautions
Drug interactions
Pregnancy
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For many products we offer a lower per unit cost when you purchase larger quantities. If your quantity is larger than what is available on this website, please contact us directly.
Brand-name and generic products are therapeutically equivalent.
Whatever source country you choose, your product will take about the same number of days to arrive.
Discreet Packaging
Your order for Sabril will be shipped in discreet packaging so whether the item is shipped to your home or work no one will know the contents of the shipment until opened.
Delivery Timetable
Average regular delivery time:
10 days from our Canadian online pharmacy.
Delivery times for Sabril do vary depending on the location of the dispensary. The reason deliveries take time is primarily due to customs procedures that need to be completed prior to allowing our packages to enter the United States. Expedited and tracked delivery services are available from our Canadian online dispensary. Please speak to one of our online pharmacy service representatives if you have any questions about delivery times for your order.
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